2024
Inside the Mind of a Dog as Self - Narrator (voice)
2024
Hot Ones Versus as Self (1 episode)
2024
The Floor as Self - Host (24 episodes)
2023
Liberty or Death: Boston Tea Party as Self - Host (4 episodes)
2023
Unstable as Ellis Dragon (16 episodes)
2023
Dog Gone as John Marshall
2022
Yankees-Dodgers: An Uncivil War as Self - Narrator (voice)
2022
The Pentaverate as Rob Lowe (6 episodes)
2022
The Andy Warhol Diaries as Self (6 episodes)
2022
The '80s: Top Ten as Self - Host (6 episodes)
2021
Attack of the Hollywood Clichés! as Self - Host / Narrator (voice)
2020
A West Wing Special to Benefit When We All Vote as Sam Seaborn
2020
The Happy Days of Garry Marshall as Self
2020
Celebrity Watch Party (1 episode)
2020
A Parks and Recreation Special as Chris Traeger
2020
The Paley Center Salutes Parks and Recreation as Chris Traeger
2020
Reunited Apart as Self (1 episode)
2020
9-1-1: Lone Star as Owen Strand (72 episodes)
2019
The Knight Before Christmas as Derek
2019
Holiday in the Wild as Derek Holliston
2019
The Kelly Clarkson Show (1 episode)
2019
I Am Patrick Swayze as Self
2019
What Just Happened??! with Fred Savage (1 episode)
2019
Wild Bill as Bill Hixon (6 episodes)
2019
Mental Samurai as Self - Host (19 episodes)
2018
Basketball: A Love Story as Self (archive footage) (1 episode)
2018
The Bad Seed as David
2018
Super Troopers 2 as Guy Le Franc
2018
Lie Detector as Self (1 episode)
2018
Calgary '88 as Self - Narrator (voice)
2017
The Orville as Darulio (2 episodes)
2017
The Lowe Files as Self (9 episodes)
2017
The Lion Guard: The Rise of Scar as Simba (voice)
2017
How to Be a Latin Lover as Rick
2017
Elton John: The Nation's Favourite Song as Self
2016
Monster Trucks as Reece Tenneson
2016
1984 – The Season That Saved Football as Narrator (voice)
2016
Comedy Central Roast of Rob Lowe as Self
2016
Chelsea as Self (1 episode)
2016
Pocket Listing as Frank Hunter
2016
The Lion Guard as Simba (voice)
2015
The Lion Guard: Return of the Roar as Sinba (voice)
2015
You, Me and the Apocalypse as Father Jude (10 episodes)
2015
Code Black as Dr. Ethan Willis (29 episodes)
2015
The Grinder as Dean Sanderson (22 episodes)
2015
Moonbeam City as Dazzle Novak (voice) (10 episodes)
2015
The 2000's: The Decade We Saw It All as Self - Narrator (voice) (4 episodes)
2015
The Late Show with Stephen Colbert as Self (1 episode)
2015
Close Up with The Hollywood Reporter as Self (1 episode)
2015
The 2000's: A New Reality as Narrator (voice) (2 episodes)
2015
Celebrity Family Feud as Self (1 episode)
2015
Beautiful & Twisted as Ben Novack Jr.
2015
I Hate Christian Laettner as Self
2015
Hot Ones as Self (1 episode)
2014
The Interview as Rob Lowe (uncredited)
2014
Variety Studio: Actors on Actors as Self (1 episode)
2014
The '90s: The Last Great Decade? as Narrator (voice) (3 episodes)
2014
Late Night with Seth Meyers as Self (1 episode)
2014
The Tonight Show Starring Jimmy Fallon as Self (2 episodes)
2014
Off Camera with Sam Jones as Self (1 episode)
2014
Drew Peterson: Untouchable as Drew Peterson
2013
Killing Kennedy as John F. Kennedy
2013
The '80s: The Decade That Made Us (6 episodes)
2013
Knife Fight as Paul Turner
2013
Prosecuting Casey Anthony as Jeff Ashton
2012
Good Mythical Morning as Self (1 episode)
2011
I Melt with You as Jonathan
2011
Breakaway as Dan Winters
2010
Young Justice as Captain Marvel (voice) (2 episodes)
2010
WWII in HD: The Air War as Narrator (voice)
2010
Conan as Self (2 episodes)
2010
Who Do You Think You Are? as Self (1 episode)
2009
Prequel: The Dawn of Lying as Brad Kessler
2009
WWII in HD (10 episodes)
2009
WWII in HD as Narrator (voice) (1 episode)
2009
Too Late to Say Goodbye as Bart Corbin
2009
The Invention of Lying as Brad Kessler
2009
Parks and Recreation as Chris Traeger (75 episodes)
2009
Parks and Recreation as Self (1 episode)
2007
Most Shocking Celebrity Moments of the 80s as Self (archive footage)
2007
Californication as Eddie Nero (6 episodes)
2007
Stir of Echoes: The Homecoming as Ted Cogan
2007
The Graham Norton Show as Self (1 episode)
2006
A Perfect Day as Rob Harlan
2006
Brothers and Sisters as Robert McCallister (78 episodes)
2006
Midnight Blue, Vol. 3: Celebrities Edition as Self (archive footage)
2005
The Christmas Blessing as Robert Layton
2005
Staying Gold: A Look Back at 'The Outsiders' as Self
2005
The Showbiz Show with David Spade (2 episodes)
2005
Thank You for Smoking as Jeff Megall
2005
Beach Girls as Jack Kilvert (6 episodes)
2005
Jiminy Glick in Lalawood as Rob Lowe
2005
The Friday Night Project (1 episode)
2004
Retrosexual: The '80s as (archive footage) (5 episodes)
2004
Perfect Strangers as Lloyd Rockwell
2004
Dr. Vegas as Dr. Billy Grant (10 episodes)
2004
Salem's Lot as Ben Mears (2 episodes)
2003
The Lyon's Den as John 'Jack' Turner (13 episodes)
2003
The Ellen DeGeneres Show as Self (3 episodes)
2003
Celebrities Uncensored as Self (1 episode)
2003
View from the Top as Co-Pilot Steve Bench
2003
Real Time with Bill Maher as Himself (2 episodes)
2003
Jimmy Kimmel Live! as Self (2 episodes)
2002
The Christmas Shoes as Robert Layton
2002
Austin Powers in Goldmember as Middle Number Two
2002
American Idol as Self (1 episode)
2002
Framed as Mike Santini
2001
Jane Doe as David Doe
2001
Good Day Live as Self (1 episode)
2001
Hard Knocks (1 episode)
2001
Primetime Glick (1 episode)
2001
Proximity as William Conroy
2000
One Hell of a Guy as Nick
2000
The Specials as The Weevil
2000
Escape Under Pressure as John Spencer
1999
The West Wing as Sam Seaborn (90 episodes)
1999
Austin Powers: The Spy Who Shagged Me as Young Number Two
1999
Atomic Train as John Seger (2 episodes)
1999
Family Guy as Rob Lowe (voice) (1 episode)
1999
Family Guy as Stanford Cordray (voice) (1 episode)
1999
Dead Silent as Kevin Finney
1998
Outrage as Tom Casey
1997
For Hire as Mitch Lawrence
1997
Crazy Six as Billie, aka Crazy Six
1997
Hostile Intent as Mike Cleary
1997
Midnight Man as Sean Dillon
1997
The View as Self (2 episodes)
1997
Contact as Richard Rank
1997
Living in Peril as Walter Woods
1997
Austin Powers: International Man of Mystery as Decapitated Henchman's Friend (uncredited)
1996
The Daily Show as Self (2 episodes)
1996
The Rosie O'Donnell Show as Self - Guest (1 episode)
1996
On Dangerous Ground as Sean Dillon
1996
Mulholland Falls as Hoodlum
1996
Fox Hunt as Edison Pettibone
1995
The Naked Truth as Rob Lowe (1 episode)
1995
Tommy Boy as Paul Burns (uncredited)
1994
Frank & Jesse as Jesse James
1994
The Stand as Nick Andros
1994
The Stand as Nick Andros (4 episodes)
1993
Late Night with Conan O'Brien as Self - Guest (1 episode)
1993
Suddenly, Last Summer as Doctor Cukrowicz
1992
The Larry Sanders Show (1 episode)
1992
The Finest Hour as Lawrence Hammer
1992
Wayne's World as Benjamin Kane
1991
The Dark Backward as Dirk Delta
1990
If the Shoe Fits as Francesco Salvitore
1990
Bad Influence as Alex
1989
The Simpsons as Cousin Peter (voice) (1 episode)
1988
This Morning as Self (1 episode)
1988
LIVE with Kelly and Mark (1 episode)
1988
Illegally Yours as Richard Dice
1988
Masquerade as Tim Whalen
1987
Square Dance as Rory
1986
Mike Tyson vs Trevor Berbick as Self
1986
About Last Night... as Danny Martin
1986
Youngblood as Dean Youngblood
1985
St. Elmo's Fire as Billy Hicks
1984
Oxford Blues as Nick De Angelo
1984
The Hotel New Hampshire as John Berry
1983
The Outsiders as Sodapop Curtis
1983
Thursday's Child as Sam Alden
1981
Entertainment Tonight as Self (1 episode)
1980
Schoolboy Father as Charles Elderberry
1979
A New Kind of Family as Tony Flanagan (11 episodes)
1975
Saturday Night Live as Self - Host (3 episodes)
1972
ABC Afterschool Special as Charles Elderberry (1 episode)
1971
Great Performances as Doctor Cukrowicz (1 episode)
1962
The Tonight Show Starring Johnny Carson as Self (1 episode)
1953
The Oscars as Self (1 episode)
1951
Hallmark Hall of Fame as Sam Alden (1 episode)
1944
Golden Globe Awards as Self - Nominee (4 episodes)