Nicole Amber Maines (born 1997) is an American actress, writer, and transgender rights activist. Prior to her acting career, she was the anonymous plaintiff in the Maine Supreme Judicial Court case Doe v. Regional School Unit 26, in which she argued her school district could not deny her access to the female bathroom for being transgender. The court ruled in 2014 that barring transgender students from the school bathroom consistent with their gender identity is unlawful, the first such ruling by a state court.

As an actress, Maines played Nia Nal on The CW superhero series Supergirl (2018–2021) in the fourth through sixth seasons. She is the first to portray a transgender superhero on television. She currently plays the recurring role of Lisa in the second season of Yellowjackets (2023–present).

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