Sally Bankes spent twenty-five years working as a bank manager before pursuing a career as a professional actress, though she had been active in youth theatre since the age of nine. Since then, she has appeared in Little Britain (2003), Doctors (2000), Two Pints of Lager and a Packet of Crisps (2001), Heartbeat (1992), and the sketch comedy show Tittybangbang.

She has also featured in other British television productions, including Coronation Street (1960) and Victoria Wood's Housewife, 49 (2005).

Based in Southport, she serves as a director of the Operatic New Generation Youth Theatre in her hometown and teaches performing arts at Southport College. Additionally, she co-hosts a Sunday morning programme on Radio Lancashire.